m64p (2021/06/21) is released. m64p uses mupen64plus-gui, a brand new mupen64plus frontend written in Qt5. It supports all thing things you’d expect from a frontend (savestate management, pausing, screenshots, etc..). m64p comes bundled with GLideN64 for the graphics plugin. It should give you the best out-of-the-box experience available for N64 gaming.

m64p changelog:
This release now includes mupen64plus's "new dynarec". It's enabled by default for new installs. For existing installs, you can enable it by going Settings->Core and Video Settings and setting "R4300Emulator" to "2". This should reduce the load on the CPU for most games.
A first for any N64 emulator: VRU (Voice Recognition Unit) support! Only 2 games made use of it: Hey You, Pikachu! and Densha de Go! (English translation here: https://www.romhacking.net/translations/2947/)
Both of these games expect the VRU to be connected to controller port 4:
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Once you click "Emulate VRU", it will begin to download an English language voice model, which is required for speech-to-text recognition. It only does this the first time.
It will download the model into the same directory as the EXE, so that directory needs to be writeable.
You need a microphone to use the VRU. You can search on YouTube for some gameplay footage of Hey You, Pikachu! to see how it's used.
Only English is supported.

Download: m64p (2021/06/21) x64
Source:Here